Semax

Molecular Weight

813.93 Da

Half-Life

10-15 minutes

Evidence Passport

Semax

Evidence strength, status, identity, route and safety are scored separately.

Reviewed 2026-08-31

Human evidence

Human source linked; classification pending

A human source exists, but its strength and applicability have not completed review.

Development status

Status not verified

Investigational development is not the same as approval or product suitability.

Identity match

Named compound linked

Sources are linked to the named compound; formulation and product quality remain separate questions.

Route relevance

Route match not verified

Catalogue route: Intranasal spray. A matching human study route is not confirmed.

Safety record

4 documented flags

Documented flags are visible, but absence of a listed risk would not prove safety.

What is still missing?

• The exact studied route and protocol have not been verified in the source record.

1 app-verified source linked · Version 2026-08-31

Compare the evidence

Mechanism of Action

A synthetic heptapeptide comprising the ACTH (4-7) fragment with a C-terminal Pro-Gly-Pro tripeptide. Targets µ-opioid receptors, regulates USP18 and deubiquitination of FTO protein. Inhibits pyroptosis and decreases oxidative stress in neuronal cells. Modulates BDNF and enhances neuroplasticity.

Research areas reported in source material

These topics describe the catalogue's research index. They are not promised outcomes or personal recommendations.

•Enhanced cognitive function
•Improved memory and learning
•Neuroprotection via µ-opioid receptor modulation
•Reduced anxiety and oxidative stress
•Promotes functional recovery after neurological injury

Safety & Risks

Nasal irritation
Possible headaches initially

Notable Research

Semax neuroprotective effects (2011)

Demonstrated significant neuroprotection in stroke models

DOI: 10.1007/s12035-011-8211-5

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Research Disclaimer: This information is compiled from published research and is provided for educational purposes only. Peptides discussed here are classified as research chemicals in most jurisdictions and are not FDA-approved for human use unless otherwise noted. Consult a qualified healthcare provider before starting any protocol.