Molecular Weight
813.93 Da
Half-Life
10-15 minutes
Administration
Intranasal spray
Longevity Score
7/10
A synthetic heptapeptide comprising the ACTH (4-7) fragment with a C-terminal Pro-Gly-Pro tripeptide. Targets µ-opioid receptors, regulates USP18 and deubiquitination of FTO protein. Inhibits pyroptosis and decreases oxidative stress in neuronal cells. Modulates BDNF and enhances neuroplasticity.
beginner
300mcg daily intranasal
intermediate
600mcg daily intranasal
advanced
900mcg daily intranasal
athlete
600mcg daily intranasal
Frequency: Daily · Duration: 30–90 days continuous, with optional 2-week breaks between cycles
Semax works both intranasally (primary clinical route) and subcutaneously. SC gives faster onset for acute nootropic use. — SC route less common; dose reduced ~3× vs intranasal.
Week 1-2
Increased mental clarity, focus
Week 3-4
Improved memory consolidation
Week 5-8
Enhanced cognitive performance
Long Term
Sustained neuroprotection, reduced neuroinflammation
Semax neuroprotective effects (2011)
Demonstrated significant neuroprotection in stroke models
DOI: 10.1007/s12035-011-8211-5Explore more peptides in this category
View All Cognitive Peptides →Research Disclaimer: This information is compiled from published research and is provided for educational purposes only. Peptides discussed here are classified as research chemicals in most jurisdictions and are not FDA-approved for human use unless otherwise noted. Consult a qualified healthcare provider before starting any protocol.