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Metabolic
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Retatrutide

Also known as: Reta

Molecular Weight

4112 Da

Half-Life

6 days

Evidence Passport

Retatrutide

Evidence strength, status, identity, route and safety are scored separately.

Reviewed 2026-08-31

Human evidence

Developing human evidence

Phase 2 evidence can show a signal without establishing approval or broad suitability.

Development status

Phase 3 development or evidence

Investigational development is not the same as approval or product suitability.

Identity match

Named compound linked

Sources are linked to the named compound; formulation and product quality remain separate questions.

Route relevance

Study protocol recorded

At least one linked source records a studied protocol; it remains study context, not an instruction.

Safety record

6 documented flags

Documented flags are visible, but absence of a listed risk would not prove safety.

What is still missing?

No major catalogue gap is flagged, but personal suitability and product quality remain separate.

3 app-verified sources linked · Version 2026-08-31

Compare the evidence

Mechanism of Action

A novel unimolecular triple agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and glucagon (GCG) receptors. Promotes satiety, enhances insulin sensitivity, increases energy expenditure via glucagon receptor activation, and significantly reduces liver fat.

Research areas reported in source material

These topics describe the catalogue's research index. They are not promised outcomes or personal recommendations.

  • Significant fat loss (up to 24.2% at 48 weeks)
  • Improved metabolic health
  • Enhanced insulin sensitivity and lipid metabolism
  • Appetite regulation
  • 86% relative reduction in liver fat (MASLD)
  • Normal liver fat achieved in 85%+ of participants

Safety & Risks

  • GI side effects initially (nausea, diarrhea)
  • Possible muscle loss without resistance training
  • Requires gradual dose titration

Notable Research

TRIUMPH-2 Phase 3 Trial (2024)

Achieved 24.2% weight loss at 48 weeks with highest dose

DOI: 10.1038/s41591-024-03018-2

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Research Disclaimer: This information is compiled from published research and is provided for educational purposes only. Peptides discussed here are classified as research chemicals in most jurisdictions and are not FDA-approved for human use unless otherwise noted. Consult a qualified healthcare provider before starting any protocol.