SLU-PP-332 is a small-molecule ERRα agonist with remarkable endurance, fat oxidation, and mitochondrial benefits. Here's the complete guide to what it does, who it's for, and how to use it.

Peptide South Africa Research Research TeamEditorial

SLU-PP-332: The ERRα Agonist That Gives You the Benefits of Exercise in a Vial

SLU-PP-332 is unlike most compounds in the biohacking world. It's not a peptide — it's a small synthetic molecule that activates estrogen-related receptor alpha (ERRα), one of the master regulators of mitochondrial biogenesis and fat metabolism. In animal studies, it produced dramatic improvements in endurance capacity without any additional training.

What Is SLU-PP-332?

SLU-PP-332 was developed by researchers at Scripps Research. ERRα is a transcription factor that regulates genes controlling:

• Mitochondrial biogenesis — building new mitochondria
• Oxidative phosphorylation — how efficiently cells produce ATP
• Fatty acid oxidation — how much fat gets burned for fuel
• Muscle fiber type switching — shifting toward slow-twitch oxidative fibers
• Upregulates PGC-1α — the primary driver of mitochondrial biogenesis
• Increases expression of genes for beta-oxidation
• Promotes type I (slow-twitch) muscle fiber characteristics
• Reduces visceral fat mass
• Improves insulin sensitivity
• Starting dose: 5mg/day oral
• Effective range: 10–25mg/day
• Frequency: Daily or 5 days on/2 days off
• Cycle length: 4–8 weeks
• Timing: Morning fasted
• SLU-PP-332 10–15mg/day oral (ERRα → biogenesis)
• MOTS-C 500mcg/day subQ (AMPK → function)
• SS-31 0.5mg/day subQ (cardiolipin → protection)
• Retatrutide 1–3mg/week
• SLU-PP-332 10mg/day oral
• AOD-9604 300mcg/day fasted subQ

Track Your Metabolic Stack

Running SLU-PP-332 alongside GLP-1s, MOTS-C, or SS-31? Peptide South Africa Research helps you track energy, recovery, body composition, and protocol adherence across your full stack.

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